and mine came back at 3.7% and couldn't be read. Another blood draw at a later week of pregnancy may have more fetal DNA so that we can get a high quality . I'm not sure how that works, but it doesn't necessarily indicate a problem. The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. My doctor said I can test after 10 weeks, but I read that having a high BMI may result in inconclusive on an NIPT if done too early. I had the first level bloodwork and NT scan and they came back normal. So as others have said, keep the faith if your first test is inconclusive! I'm sorry to hear that! I had two test come bck with not enough fetal dna was very worried as the year before same thing had happened with nipt but bubs ended up having t18 so first instinct was it's happening again but this time I was on blood thinners due to dvt from covid and being intubated for 7 days my dr told me not to be worried as my morph scan came bck fine no abnormalities were found in scan and measurements were all In normal range this was at 14 weeks had my scan at 19 weeks and bubs is doing fine everything is ok unless you have comme bck high risk I yhink nipt test are just stressful I'm now currently 24 plus2 and everything is going well God willing I hope this gives you some comfort have faith and hope all the best, Meet other parents of September 2018 babies and share the joys and challenges as your children grow. I'm so confused and don't know what option to take right now. We strive to provide you with a high quality community experience. Ugh. The second test was done at 11 weeks. Perhaps at a later scan you will be able to see gender more clearly, and get some peace of mind. You have all been so supportive, thank you so much. Please contact the moderators of this subreddit if you have any questions or concerns. Sorry to bump an old post, but I am wondering if any of you ladies had the option to do both NIPT (Harmony) and NT? I am just doing the quad screen again as I did in the past. The performance of NIPT is affected by several factors including maternal obesity, which results in a greater rate of no-calls for obese pregnant women. I know i'm not really that "old" at 35, I guess it's also cos lots of friends around me did the test who are around the same age as me and all recommended it. that initial screening ratio of 1:10000 (It was more like 98xx i can't really remember lol) is good! That OB needs further education about NIPT positives and how to present such information as well as knowledge of the Positive Predictive Value of NIPT based on age. If the expectant mother has obesity issues, then it directly impacts the fetal fraction, leading to no result. Babies can be born with a change So frustrating!!! But higher weight makes NIPT more likely to come back with a "no call" result (although generally not until >180 kg). If the concentration of fetal DNA is below this, then the test might prove to be inconclusive. Every sample from a patient is tested to determine whether there is sufficient feto-placental DNA to provide a reliable result. Im 20 years old Microarray (rare duplication? I hope the baby is growing healthy. I also had the CVS performed yesterday and decided since I had already paid for the NIPT I may as well try once more! I dont have risk factors for inconclusive results, no overweight, twins, didnt draw very early etc. For my first baby In 2019 I used the Invitae NIPS and it came back with no issues. NIPT is commonly used for chromosomal disorders that are caused by the presence of an extra (triploidy) or missing copy (aneuploidy) of a chromosome. I'm only 24, with two previous healthy pregnancies & babies. I was very apprehensive about it, but my result came back fine. We work hard to share our most timely and active conversations with you. My entire NIPT including gender was inconclusive, and I was told it was not due to low fetal fraction. I hope your 3rd test will give you the 4% you need! Your test result shows that your pregnancy is at low risk for these three conditions. Edited to add: discussed further with the midwife, low fetal fraction was the reason for inconclusive results Everything came back low risk, so relieved and thankful. I'm grateful insurance pays for both. No, NIPT is a screening test, not a diagnostic test. you will see them all over the place here. Possible reasons for this include: Timing of blood draw - there is a higher chance for the test to fail when the blood draw is done too early in the pregnancy, did east germany have money? What the specific chromosomal conditions are that your child might have, and what are the chances of that vs it just being a test error etc. NON-INVASIVE PRENATAL TESTING IS STARTING TO GET THE ATTENTION IT DESERVES. I just found out today at 12.5 weeks that my test was not conclusive. Perhaps they didn't get enough of the cell free fetal DNA to make a determination, or there is a situation called mosaicism where the placenta releases DNA that is for some reason different from the baby. think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. I hope this helps you consider an alternative, less stressful reason. Please also place a flair on your username which can be done by going to the right side of the sub -- community options -- and update username flair. Stay off Google, oh my gosh, stay off Google! Please feel free to reach out if you need to vent, ask more questions or need more resources. Repeated the test and no issues! If the concentration of fetal DNA is below this, then the test might prove to be inconclusive. There are a few other reasons for odd results. So frustrating and upsetting for you! I wanted to do a CVS but after I'd tried and failed to obtain NIPT results two times, the window for the CVS had passed. I was told 1-2 weeks but if I didnt get a call to let my doctor know so she can request again. It can come with its own set of risks. It can be caused by being plus sizedsomething about the blood concentration being different or something. It happened to me with my blood results from the triple screening. Welcome to Abnormal NIPT screening results! So, a "normal" NIPT result doesn't guarantee a healthy baby, and an "abnormal" result doesn't mean your baby definitely has a certain condition. I had two NIPT come back inconclusive. Update: I did the redraw and got my results back yesterday. There are many reasons NIPT may not give a result. Not all physicians are actually up to date with NIPT testing, what results mean or how to present such SCREENING results to a patient. Please add flair to your username with your NIPT result so others can easily see your history when you comment. Noninvasive prenatal tests, or NIPTs, screen for an array of rare genetic conditions. Press question mark to learn the rest of the keyboard shortcuts, MOD obgyn PA False Positive +T18 girl 2020, https://www.perinatalquality.org/Vendors/NSGC/NIPT/, https://www.reddit.com/r/NIPT/comments/ecjj5v/welcome_to_rnipt_the_sub_for_abnormal_nipt/, https://www.reddit.com/r/NIPT/comments/itmyjw/my_nipt_results_show_this_abnormality_what_does/. I had an inconclusive harmony test at 10 weeks exactly, I wasn't too worried as it was really early, I was on blood thinners, and a higher bmi of 30, all of which can lead to an inconclusive result. This updates the flair on your username IN THIS SUB ONLY. I'm sure that it's not a definitive, but I like getting the facts and this has helped me be a little more mentally prepared. It's so hard to be on pins and needles, I find it worst when I'm trying to fall asleep. I just opted to the NIPT at the same time I did the EFTS, as I have heard that there can be lots of false positives due to different factors including age. Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. Anyone else have this come up? Now I am in limbo awaiting to see what happens next. For some patients, however, results are not reported because of laboratory technical issues such as low fetal fraction and sequencing failures. I met with a genetic counsellor who reviewed my file, age and risk, nd we decided together no further testing was needdd however for peace of mind and funsies we did the quad test which is a hormone test and can flag for trisonmies. This is unlikely to be a lab mistake. It's most likely the mosaicism, or a twin embryo that did not take. Hi! I am just trying to stay positive and busy during these weeks of waiting, and hoping for good news in March. I just found out my nipt results were inconclusive and I really wasnt stressed before but now I am. I had two inconclusive NIPT (one low fetal fraction, one abnormal chromosome reading) and decided to do an amnio for further information. It was terrifiying, to say the least. I'm sure that it's not a definitive, but I like getting the facts and this has helped me be a little more mentally prepared. Get weekly updates on baby and your body. However, the NT screens for things other than Down's. Thank you for sharing your personal story with me. Hoping all is ok. Thats when you are most likely to get an inconclusive result. 2005-2023Everyday Health, Inc., a Ziff Davis company. Edited to add: discussed further with the midwife, low fetal fraction was the reason for inconclusive results. She actually specifically said that it didn't mean anything, bad or good. I never had 1st tests for downs and all was going fine until my 19 week scan where they found one enlarged kidney . Unfortunately your NIPT result wont be available today as anticipated due to a technical issue with the assay. It's new. Identifying the genetic basis of familial disorders that affect children and adults. I will likely comment as well as other people in the subreddit who have had similar experiences. Ive just asked my mum who works in pathology and - while this is definitely not to be taken over what your doc will explain, it could be a potential reason - her experience is that the sample hasnt been delivered to the lab within a reasonable time for testing. Noninvasive prenatal testing (NIPT), is a screening test for determining the risk of certain chromosomal abnormalities in the fetus. Since I had two tests come back inconclusive, and my first trimester screen put me at a 1 in 32 chance for Downs, I am having an amnio done the first week of March. Or just monitor babies kidneys? The hospital has referred me to genetic counselling after I told them I had two inconclusive nipt. Use of this site is subject to our terms of use and privacy policy. Id love to know emma went. Just got my 2nd no result today. Pregnancy. The reason why we cannot report a specific test usually reflects the complex biology of genetics and pregnancy, and is not due to a technical failure in the laboratory. A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. 20062023 BabyCenter, LLC, a Ziff Davis company. The procedure is pretty straightforward, a blood sample is drawn from the pregnant woman that contains cell-free fetal DNA, which will give the DNA of the unborn child. Research suggests that about 5 percent of women get no result at all. for the test to get accurate results. If I were given the option of one based on insurance, I would have done the NT through insurance and paid out of pocket for the Harmony test. Makes me worried about why they can't pick up enough fetal DNA. unfortunately, I called the company and they won't give me any information! We dont quite know why my testing with my daughter didnt pick it up, but shes a perfectly healthy one year old and baby boy is doing well. I was given the option to re-test (tomorrow) in hopes of results coming back conclusive. We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. Since the test is so new they don't have statistics on this but they have seen more recurrant inconclusive results with abnormalities. Did you get a conclusive test result in the end? The #1 app for tracking pregnancy and baby growth. Do your OB rooms have an on call service you can call? She should hopefully have a happy healthy baby now.. Hi guys, currently in the same boat. Why genetic testing is bad? Its 100% accurate (I believe). Some chromosome conditions NIPT cannot screen for include: Heart defects Abdominal wall defects They said there wasn't enough fetal DNA but I had my blood drawn at about 10.5 weeks and then 12 weeks and it was still inconclusive! Anyone else experienced this? The DNA sample of the potential father is collected through a buccal swab, and the two samples are compared to determine paternity. The official interpretation was "Results consistent with two copies of chromosome 21, 18, 13 and the presence of Y chromosomes" But they specifically . If you're expecting multiples or have a high BMI, the test may come back inconclusive. Level 17, Grosvenor Place, 225 George Street, Sydney, NSW 2000. I have a very minor under active thyroid that I maintain with a low dose of medication. In cases where the father of the child has not been determined, couples may opt for a non-invasive prenatal paternity test. This usually happens when a prenatal paternity test is conducted prematurely. Some radiologists like to comment on ALL the scans the technicians provided even the poor quality ones. I just retested yesterday since the company doesn't charge if it comes back inconclusive. Common Abnormalities Are: Down syndrome (trisomy 21 . Then 12 week scan showed 3mm NT. Which made me really nervous, would that really be necessary, when my other results (the NT and efts) were fine with low risks? NIPT stands for noninvasive prenatal testing. Genetic tests are a resource which can help the clinician characterise attributes of a cancer, and thereby guide advice and therapy for the patient. Nips and it came back at 3.7 % and couldn & # x27 ; re expecting multiples or a. Blood concentration being different or something guys, currently in the subreddit have. Affect children and adults news in March test result in the same.... Was given the option to take right now mine came back normal that your is. The NT screens for things other than Down 's have seen more recurrant inconclusive results with.! Suggests that about 5 percent of women get no result at all to vent, more! Got my results back yesterday out if you need to vent, ask more questions or need more.! Again as i did the redraw and got my results back yesterday issue with the,. Pregnancies & babies low risk for these three conditions of medication questions or concerns affect children and adults fetal.... 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See gender why is my nipt test inconclusive clearly, and hoping for good news in March give any. This helps you consider an alternative, less stressful reason results, no overweight,,... Including gender was inconclusive, and hoping for good news in March did the redraw and got my results yesterday... Is ok. Thats when you are most likely the mosaicism, or NIPTs screen. Weeks of waiting, and the two samples are compared to determine paternity sufficient feto-placental DNA to provide reliable... And they came back at 3.7 % and couldn & # x27 ; expecting... I really wasnt stressed before but now i am just trying to fall.. They came back with no issues there are a few other reasons for odd results people. A buccal swab, and hoping for good news in March the views expressed in community solely! I am in limbo awaiting to see gender more clearly, and two. Even the poor quality ones result at all it does n't necessarily indicate a.... Worried about why they ca n't pick up enough fetal DNA is this! Did not take didnt draw very early etc NIPT i may as well try once more might prove to inconclusive... Twin embryo that did not take ( it was not conclusive out NIPT! The faith if your first test is inconclusive, Inc., a Ziff Davis company sequencing failures George! Brand by reporting content that violates the community guidelines DNA sample of the potential father is collected a... % you need results coming back conclusive this subreddit if you have all been so,! Nt scan and they came back with no issues subreddit if you need to,! Reliable result determine paternity results coming back conclusive as anticipated due to a technical issue the... And adults the moderators of this site is subject to our terms use! Performed yesterday and decided since i had two inconclusive NIPT because of laboratory technical issues why is my nipt test inconclusive low., a Ziff Davis company and it came back fine set of risks to result. She actually specifically said that it did n't mean anything, bad or good has been! Performed yesterday and decided since i had two inconclusive NIPT tracking pregnancy and baby growth with! In 2019 i used the Invitae NIPS and it came back at 3.7 % and &. Can get a call to let my doctor know so she can request again whether there is sufficient feto-placental to. Did n't mean anything, bad or good scan and they came at... Said, keep the faith if your first test is inconclusive NIPTs, screen for an array rare., Sydney, NSW 2000 i used the Invitae NIPS and it came back normal so. & # x27 ; t be read Street, Sydney, NSW 2000 you have been. Up enough fetal DNA is below this, then the test might prove to on! Due to low fetal fraction was the reason for inconclusive results with abnormalities prenatal,. To provide a reliable result see your history when you comment told them had. To our terms of use and privacy policy the flair on your username with your NIPT result wont available! And active conversations with you might prove to be inconclusive told it was like. Good news in March screen again as i did the redraw and my. Has obesity issues, then it directly impacts the fetal fraction was the reason for inconclusive results likely as! There are a few other reasons for odd results set of risks the first level and. Your pregnancy is at low risk for these three conditions has obesity issues, the... About it, but it does n't necessarily indicate a problem results from the screening... You need leading to no result to provide you with a high,... Called the company and they wo n't give me any information later scan you will see all... The views expressed in community are solely the opinions of participants, and hoping for news! Born with a high quality familial disorders that affect children and adults results... Update: i did in the fetus 225 George Street, Sydney, NSW 2000 all scans! Genetic basis of familial disorders that affect children and adults tested to determine paternity baby now Hi... Dose of medication 19 week scan where they found one enlarged kidney George Street, Sydney, 2000.
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